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Back pain can have causes that aren't due to underlying disease. Examples include overuse such as working out or lifting too much, prolonged sitting and lying down, sleeping in an uncomfortable position or wearing a poorly fitting backpack. What are 3 causes of back pain? Causes Muscle or ligament strain. Repeated heavy lifting or a sudden awkward movement can strain back muscles and spinal ligaments. ... Bulging or ruptured disks. Disks act as cushions between the bones in the spine. ... Arthritis. ... Osteoporosis. ... Ankylosing spondylitis, also called axial spondyloarthritis.