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What is the proper management of headache? Rest in a quiet, dark room. Hot or cold compresses to your head or neck. Massage and small amounts of caffeine. Over-the-counter medications such as ibuprofen (Advil, Motrin IB, others), acetaminophen (Tylenol, others) and aspirin. What is the fastest way to stop a headache? Find a calm environment Turn off the lights. Light and sound can make migraine pain worse. Relax in a dark, quiet room. ... Try temperature therapy. Apply hot or cold compresses to your head or neck. ... Sip a caffeinated drink. In small amounts, caffeine alone can relieve migraine pain in the early stages.